Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶,其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成,具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 273 | 现货 | ||
25 mg | ¥ 432 | 现货 | ||
50 mg | ¥ 673 | 现货 | ||
100 mg | ¥ 989 | 现货 | ||
200 mg | ¥ 1,460 | 现货 | ||
500 mg | ¥ 2,470 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 235 | 现货 |
产品描述 | Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor, Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels. |
体外活性 | Divalproex sodium enhances apoptosis, IM-induced cell growth inhibition and cell cycle arrest in K562-G and K562-S cells. It enhances the inhibitory effects of IM on SIRT1 expression in K562-G and K562-S cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. |
体内活性 | Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas 50 mg/kg has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. |
别名 | Valproate semisodium, Epival, 双丙戊酸钠 |
分子量 | 310.41 |
分子式 | C8H16O2·C8H15O2·Na |
CAS No. | 76584-70-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 57 mg/mL (183.6 mM)
DMSO: 75 mg/mL (241.62 mM), Sonication is recommended.
Ethanol: 58 mg/mL (186.8 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO / Ethanol | 1 mM | 3.2215 mL | 16.1077 mL | 32.2155 mL | 80.5386 mL |
5 mM | 0.6443 mL | 3.2215 mL | 6.4431 mL | 16.1077 mL | |
10 mM | 0.3222 mL | 1.6108 mL | 3.2215 mL | 8.0539 mL | |
20 mM | 0.1611 mL | 0.8054 mL | 1.6108 mL | 4.0269 mL | |
50 mM | 0.0644 mL | 0.3222 mL | 0.6443 mL | 1.6108 mL | |
100 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8054 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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